Projects

We are intrigued, challenged, and motivated by the complexity of the immune system, particularly as this pertains to understanding the variation that is observed between individuals, populations, and species. Central to almost all of our work are the complicated genomic regions that encode immune receptors (immunoglobulins and T cell receptors), which are critical to adaptive immunity. The complexity of these gene regions has historically made them difficult to study at the genomic level, and as a result, we still have much to learn about their role in disease and in various clinical contexts.

 

Our lab develops and leverages novel tools to: (1) better characterize variation in these loci in both human populations and species of biomedical relevance: and (2) delineate the impact of immune receptor diversity in B cell and T cell mediated immunity.